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Image Search Results
Journal: Journal of advanced research
Article Title: SAP deficiency aggravates periodontitis possibly via C5a-C5aR signaling-mediated defective macrophage phagocytosis of Porphyromonas gingivalis.
doi: 10.1016/j.jare.2022.10.003
Figure Lengend Snippet: Fig. 2. SAP deficiency aggravates periodontitis and inflammation. (a) Micro-CT 3D reconstruction images of the maxilla of wildtype and SAP-KO mice. (b) CEJ-ABC distance was analyzed from Micro-CT images (n = 5). (c) Histological images of H&E and TRAP staining, and representative CD34 and CD45 immunohistochemistry images of the periodontium in wildtype and SAP-KO periodontitis mice. Quantitative analysis of CEJ-ABC distance (d) and osteoclasts (e) from histological images (n = 5). Quantitative analysis of CD34 (f) and CD45 (g) positive cells from immunohistochemistry images (n = 3). (h-j) Inflammatory cytokine mRNA expression in the periodontium of wildtype and SAP-KO periodontitis mice (n = 3). (k-m) Protein level expression of inflammatory cytokines detected by ELISA (n = 5). Red dot line, CEJ level; Black dot line, ABC level; Blue double arrow line, CEJ-ABC distance. Yellow ‘‘R”, tooth root; Yellow ‘‘B”, alveolar bone. Black arrow, osteoclasts. Data are presented as mean ± SD. The significant difference among the groups, *p < 0.05, **p < 0.01, ***p < 0.001, ns, not significant. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Article Snippet: The protein level of SAP in the human gingival lysate was analyzed using the
Techniques: Micro-CT, Staining, Immunohistochemistry, Expressing, Enzyme-linked Immunosorbent Assay